Figure 3 | Scientific Reports

Figure 3

From: Dual-probe molecular MRI for the in vivo characterization of atherosclerosis in a mouse model: Simultaneous assessment of plaque inflammation and extracellular-matrix remodeling

Figure 3

Influence of the gadolinium-based elastin-specific probe on the visualization of iron-oxide-particles and vice versa. If a multi-target approach is chosen, it is of high clinical importance, that the respective imaging probes do not affect the measurements on the other probe. (A) To investigate the influence of iron-oxide-particles on the assessment of the elastin-specific-agent on T1-weighted images, imaging was performed on day one prior to the administration of the iron-oxide-particles and 24-hours following the administration of the iron-oxide-particles. CNR-measurements of the elastin-specific MR-probe showed a strong correlation between both days. (B) To investigate the influence of the gadolinium-based probe on the assessment of the iron-oxide-particles on T2*-weighted-sequences, imaging was performed on day two prior to and following the administration of the elastin-specific probe. The assessment of the effect of iron-oxide-particles on T2*-weighted images prior to the administration of the gadolinium-based probe demonstrated a strong correlation with measurements following the administration of the gadolinium-based probe.

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