Figure 5

Glioma recurrence with restricted diffusion. Semi-automated delineation (IC80) of lesion VOI based on PET (a) was transferred to the respective ADC map (b). The following panels show post-contrast T1W (c) and a 3D lesion model (d) for illustration. Each row (α, β, γ) shows a patient with recurrence. While TBRmax is above the clinically established threshold (TBRmax > 2) suggesting recurrence, ADCmean shows lower readings (ADCmean < 900) indicating diffusion restriction due to high tumour cellularity.