Figure 5
From: Network-based method for drug target discovery at the isoform level
Non-APPRIS annotated target major isoforms. (A) Clusters in the breast cancer type-based isoform coexpression network. (B) All connected nodes of isoforms of the target gene TYMS. Gray indicates common neighbors, yellow denotes the specific neighbors of the target major isoform and red represents the specific neighbors of the alternative isoform. (C) Ratio of the number of significant neighboring isoforms of the genes TYMS, TUBB and DNMT1 with the genes perturbed by the drugs trifluridine, colchicine and azacitidine in each common gene set. The ratio distributions for isoforms of TYMS and TUBB are significantly different (Mann-Whitney, p–value = 0.009026 and 0.0001554). (D) Overlapping biological functions between the target isoforms of TYMS and drug perturbation genes. The connections among each biological process were generated by the REVIGO website54 and illustrated by Cytoscape. (E) Structural differences between two isoforms and their affinity activity.
