Table 2 Medians (Lower and Upper Quartiles) or Counts (%) for potential clinical predictors for sPTB <37 weeks and <34weeks.

From: Trace biomarkers associated with spontaneous preterm birth from the maternal serum metabolome of asymptomatic nulliparous women – parallel case-control studies from the SCOPE cohort

 

Cork

Auckland

Term Birth

N = 109

Spontaneous Preterm Birth

<37w

N = 55

p-value

<37w vs term

Spontaneous Preterm Birth

<34w

N = 16

p-value

<34w vs term

Term Birth

N=102

Spontaneous Preterm Birth

<37w

N = 55

p-value

<37w vs term

Spontaneous Preterm Birth

<34w

N = 13

p-value

<34w vs term

Maternal height (cm)

165 (161, 168)

165 (160, 168)

0.99

167 (160, 169)

0.48

165 (161, 169)

165 (162, 168)

0.8

164 (162, 168)

0.53

Infant sex

Female

47 (43%)

24 (44%)

>0.99

7 (44%)

1 *

47 (46%)

24 (44%)

0.9

4 (31%)

0.38*

Male

62 (57%)

31 (56%)

 

9 (56%)

 

55 (54%)

31 (56%)

 

9 (69%)

 

Smoking in pregnancy

no smoking

82 (75%)

40 (72%)

0.78 §

10 (62%)

0.33*

92 (90%)

44 (80%)

0.06* § 0.03*,

12 (92%)

1*

quit

17 (16%)

8 (15%)

0.66

3 (19%)

7 (7%)

4 (7%)

1 (8%)

current smoker

10 (9%)

7 (13%)

 

3 (19%)

3 (3%)

7 (13%)

0

Fertility Treatment

7 (6%)

2 (4%)

0.72*

2 (13%)

0.32*

11 (11%)

7 (13%)

0.92

2 (15%)

0.64*

Previous Miscarriage

15 (14%)

10 (18%)

0.61

4 (25%)

0.26*

15 (15%)

6 (11%)

0.67

2 (15%)

1*

Gravidity

1

91 (83%)

43 (78%)

0.55*

12 (75%)

0.39*

73 (72%)

37 (67%)

0.36*

8 (62%)

0.35*

2

13 (12%)

10 (18%)

2 (13%)

23 (23%)

11 (20%)

3 (23%)

3 or more

5 (5%)

2 (4%)

2 (13%)

6 (6%)

7 (13%)

2 (15%)

Vaginal bleeding before 15 w visit

23 (21%)

23 (42%)

0.01

9 (56%)

0.01*

22 (22%)

14 (25%)

0.72

3 (23%)

1*

Any infection before 15 w visita

26 (24%)

11 (20%)

0.72

5 (31%)

0.54*

45 (44%)

24 (44%)

>0.99

6 (46%)

1*

  1. P-values are from tests of case-control differences using the Mann-Whitney test (Continuous variables), Chi-squared test (categorical variables with adequate counts) or Fisher’s exact test (*). §p-value for the three categories. p-value for current smoker vs no smoking in pregnancy. aAny infection during pregnancy means upper respiratory or urinary tract infection, pyelonephritis, gastrointestinal infection, vaginal candidiasis or other infections.