Table 1 NIPT for paternal inheritance of rs713040.

Sample	Fetal Fraction	VAF	Num. Mol.	LR	NIPT	Neonate GT
35A	0.088	0.004	1159	1.5e + 09	0/0	0/0
07B	0.272	0.009	482	5.9e + 15	0/0	0/0
38C	0.081	0.033	572	2.1e − 09	0/1	0/1
49E	0.174	0.961	436	2.0e − 08	0/1	0/1
38B	0.228	0.998	871	4.3e + 27	1/1	1/1
52E	0.128	0.998	248	4.7e + 04	1/1	1/1
17D	0.172	0.998	585	1.6e + 13	1/1	1/1
18C	0.123	0.998	636	3.6e + 09	1/1	1/1
52F	0.213	0.998	447	5.2e + 13	1/1	1/1
04B	0.045	0.998	2742	7.1e + 09	1/1	1/1
36C	0.144	0.998	755	1.4e + 14	1/1	1/1
02A	0.289	0.998	1497	5.1e + 64	1/1	1/1
40B	0.237	0.998	988	2.7e + 33	1/1	1/1
37A	0.209	1.000	2900	1.4e + 84	1/1	1/1

Assays were performed to measure the fetal fraction, variant allele fraction, and number of input HBB DNA molecules. The likelihood ratio of sequencing error vs paternal inheritance was then used to infer the fetal genotype. The actual genotype of the fetus is confirmed by genotyping of the newborn.

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