Table 1 Mankin score (criteria for histological evaluation).

From: RETRACTED ARTICLE: Chondro-protective effects of polydatin in osteoarthritis through its effect on restoring dysregulated autophagy via modulating MAPK, and PI3K/Akt signaling pathways

Item

Grade/classification

Grade

Structural intergrity

Normal

0

Irregular Surface

1

Pannus formation

2

Fissures into transitional layer

3

Fissures into emmiting layer

4

Fissures into calcified layer

5

Complete disorganization

6

Cells

Normal

0

Hypercellularity

1

Cloning

2

Hypocellularity

3

Safranin-O staining

Normal

0

Slight reduction

1

Moderate reduction

2

Severe reduction

3

No dye noted

4

Tidemark intergrity

Normal

0

Disruption

1