Figure 1 | Scientific Reports

Figure 1

From: Prognostic Significance of Apparent Diffusion Coefficient in Hepatocellular Carcinoma Patients treated with Stereotactic Ablative Radiotherapy

Figure 1The alternative text for this image may have been generated using AI.

Early ADC change before HCC lesion reduction obtained at baseline and at different times post-SABR. A 71-year-old man with hepatitis B virus-related liver cirrhosis and a 2.8 cm HCC in segment 7. At baseline MRI, the lesion shows strong enhancement in the arterial phase (A-phase) and washout in the portal venous phase (PV-phase), with moderate hyperintensity on DWI (b = 500) and an ADC of 1.37 × 10−3 mm2/s. At the 2-month follow-up, the lesion was stable in size by mRECIST. Lower hyperintensity at DWI was noted with a corresponding ADC of 2.00 × 10−3 mm2/s (a 46% increase). Geographic parenchymal hyperenhancement was noted in both the A- and PV-phases, consistent with focal liver reaction to SABR. At the 5-month follow-up, the lesion had a lower enhancement size (1.9 cm), indicative of partial response, with resolution of geographic parenchyma hyperenhancement. At the 8-month follow-up, no enhancement was observed, indicating complete response. Continuous volume loss of the overlying liver parenchyma was observed at 5 and 8 months.

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