Figure 4 | Scientific Reports

Figure 4

From: Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

Figure 4

V565 distribution and co-localisation with CD14+ cells in colon biopsy sections from ulcerative colitis patients after receiving oral V565 over 7 days. Colon biopsy sections were prepared as in Fig. 3. Sections were incubated with anti-V565 rabbit polyclonal antibody SY7915 and mouse anti-human CD14-FITC. Anti-V565 SY7915 binding was detected with anti rabbit IgG-Alexa 594. Hoechst 33342 was used for nuclear fluorescence, (blue). V565 and CD14 associated fluorescence are red and green, respectively. Bar = 10 μm, Arrows indicate V565 binding on CD14+ cells.

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