Figure 5
From: Thermogenic crosstalk occurs between adipocytes from different species
Transplanted murine A1KO adipocytes induced expressions of mouse and canine Ucp1 and mouse Pparg. (A) UCP1 expression (brown staining) in a representative example of a dog (CH) paraffin embedded adipose tissues. A1KO: aldehyde dehydrogenase a1 (Aldh1a1) knock out adipocytes. WT: wild type murine adipocytes. C: microcapsule. (B–E) Normalized expressions of mouse (inside microcapsules) or canine (host tissues) genes were compared between A1KO (aldehyde dehydrogenase a1 (Aldh1a1) knock out) cell-implanted or WT (control wild type) cell-implanted region (left or right region of the same dog). Student paired t-test. Ucp1, uncoupling protein 1 (B,D); Pparg, Peroxisome proliferator-activated receptor gamma (C); CoxIV, Mitochondrial cytochrome c oxidase subunit IV (E).
