Figure 2 | Scientific Reports

Figure 2

From: Structural analysis of fungal pathogenicity-related casein kinase α subunit, Cka1, in the human fungal pathogen Cryptococcus neoformans

Figure 2

Overall structure of cnCka1-CX-4945. cnCka1 is shown in magenta and CX-4945 in yellow. (a) Structure of cnCka1-CX-4945 showing its N-terminus, C-terminus and ATP-binding pocket. (b) Electrostatic potential map depicting the hydrophobic pocket at the ATP-binding site where the inhibitor CX-4945 binds. Basic regions are shown in blue, acidic regions in red and hydrophobic regions in white. (c) 2Fo-Fc map showing the binding of CX-4945 at the ATP-binding cleft contoured at 2.0 σ. (d) Interaction between cnCka1 residues and CX-4945. Hydrogen bonds are depicted as brown dashed lines and the electrostatic interaction is depicted as a green dashed line.

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