Figure 4

Structural comparisons among CK2α orthologues. cnCka1, zmCK2α, hsCK2α and pfCK2α are shown in magenta, gold, cyan and green, respectively. Mg²⁺ ions are shown as spheres and the respective co-substrates (analogues) are shown as sticks in the same colour. (a) Superimposition of cnCka1-AMPPNP-Mg²⁺ and zmCK2α-AMPPNP-Mg²⁺ (PDB code: 1LP4) with a magnified view of the AMPPNP-Mg²⁺ bound catalytic site. (b) Structural deviations at the N-lobe of cnCka1-AMPPNP-Mg²⁺, zmCK2α-AMPPNP-Mg²⁺ (PDB code: 1LP4), hsCK2α-AMPPNP (PDB code: 2PVR) and pfCK2α-ATP (PDB code: 5XVU).