Figure 7 | Scientific Reports

Figure 7

From: Structural analysis of fungal pathogenicity-related casein kinase α subunit, Cka1, in the human fungal pathogen Cryptococcus neoformans

Figure 7

Deviations in protein-inhibitor interactions when CX-4945 is bound. The cnCka1-CX-4945 structure is shown in magenta and the hsCK2α-CX-4945 (PDB code: 3PE1) structure is shown in cyan. CX-4945 is shown in yellow. Hydrogen bonds are depicted as brown dashed lines and electrostatic interactions are depicted as green dashed lines. Superimposition of the cnCka1-CX-4945 and hsCK2α-CX-4945 structures showing the residues around the catalytic cleft. (a) Interaction of His159 (His160 in hsCK2α), (b) Arg46 (Arg47 in hsCK2α) and (c) Thr112 (Phe113 in hsCK2α) with CX-4945.

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