Table 1 Hematologic data and liver function test of Swiss mice immunized with nano-iCnB.

From: Inactivated alpha toxin from Clostridium novyi type B in nano-emulsion protect partially protects Swiss mice from lethal alpha toxin challenge

Parameters

Nano-milliQW

Non-immunized-control

Nano-iCnB

Non-immunized-challenged

Reference

Total Leukocytes, (mm3)

9600 (864)ns

8466 (982)

11733 (499)

12933 (7128)

4300–10000, (mm3)

Hemoglobin, (g/dL)

14,73 (0,51)ns

10,60 (2,80)

16,17 (0,51)

20,73 (1,80)*

13–17, (g/dL)

Hematocrit, (%)

44,33 (1,53)ns

38,80 (4,50)

48,67 (1,53)

64,67 (3,05)*

39–51, (%)

Alanine Transaminase (ALT), (U/L)

38 (12)ns

32 (12)

31 (11)

211 (73)*

26–60, (U/L)

Aspartate aminotransferase (AST), (U/L)

130 (65)ns

156 (38)

180 (49)

414 (72)*

81–184, (U/L)

Alkaline phosphatase (AP), (U/L)

125 (74)ns

183 (7,20)

190 (6)

206 (28)

63–196, (U/L)

  1. Non-immunized-control (healthy animals); nano-milliQW; nano-iCnB; Non-Immunized-challenged with 157 LD50.g−1. ns – not significant - sera from Swiss mice non-immunized-control vs sera from Swiss mice inoculated with nano-milliQW. *significant - hemoglobin (p < 0.05); hematocrit (p < 0.05); ALT (p < 0.04); AST (p < 0.01) sera from immunized Swiss mice vs Non-immunized-challenged.
Back to article page