Table 3 Summary of 2 and 4-way ANOVA for Cd.

Treatments	Heart	Kidney	Liver
Treatments	Pr(>F)
	F₀ Generation
Cadmium concentration^a-0	<0.001	<0.001	<0.001
Sex^b-0	<0.001	<0.001	<0.001
Cadmium concentration: Sex^c-0	<0.001	<0.001	<0.001
Residuals	—	—	—
	F₁ Generation
Cadmium concentration^a	<0.001	<0.001	<0.001
Sex^b	0.303	<0.001	<0.001
Diet^c	<0.001	<0.001	0.018
Exposure time^d	0.592	<0.001	0.286
Cadmium concentration: Sex*	0.495	<0.001	<0.001
Cadmium concentration: Diet*	<0.001	<0.001	0.002
Sex: Diet*	0.685	0.004	0.535
Cadmium concentration: Exposure time*	0.284	<0.001	0.724
Sex: Exposure time*	0.217	<0.001	0.006
Diet: Exposure time*	0.282	<0.001	0.769
Cadmium concentration: Sex: Diet**	0.602	0.061	0.557
Cadmium concentration: Sex: Exposure time**	0.109	<0.001	0.001
Cadmium concentration: Diet: Exposure time**	0.187	<0.001	0.932
Sex: Diet: Exposure time**	0.067	0.094	0.057
Cadmium concentration: Sex: Diet: Exposure time***	0.029	0.238	0.006
Residuals	—	—	—

^a-0Indicates whether Cd concentration in F0 was significantly different among the three Cd exposure levels.
^b-0Indicates whether Cd concentration in F0 was significantly different between male and female.
^c-0Indicates whether the difference of Cd concentration between male and female was significantly different among the three different Cd exposure levels.
^aIndicates whether Cd concentration in F1 was significantly different among the three Cd exposure levels.
^bIndicates whether Cd concentration in F1 was significantly different between male and female.
^cIndicates whether Cd concentration in F1 was significantly different between HFD and LFD.
^&Indicates whether Cd concentration in F1 was significantly different between 10 and 24 weeks exposure.
^dTwo-way interaction term indicates whether the difference of Cd concentration in F1 between two levels of one factor was significantly different among the different levels of the other factor; ** indicates three-way interactions and *** indicates four-way interactions.

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