Figure 2

Rooted ML tree based on the concatenated sequences used for MLST (TP0548 and TP0488). The tree is based on 1,773 nts and 1,000 bootstrap replicates. Bootstrap values from 80–100% are highlighted as light blue circles of respective size. NHP species and/or GenBank accession numbers of published strains are provided in parentheses following the name of the strain. In all cases were the species is not mentioned, sequences are from TP of human origin. Blue = subsp. pallidum, green = subsp. pertenue, red = subsp. endemicum. The pathogen causing rabbit syphilis, Treponema paraluisleporidarum ecovar Cuniculus strain Cuniculi A, is used as an outgroup. The bar refers to substitutions per site.