Figure 3
Controlling ERK and AKT based on the influence analysis. (a) 2D influence space of ERK and AKT in B2009. SERK and SAKT represent the influence of each node on ERK and AKT, respectively, in Fig. 2. (GERK, GAKT) denotes the direction of the control goal state. (b) Composite measure (CM) is defined and used to examine how close each influence state is to the desired state of control goal (see Methods section for the definition of CM). Smaller with positive sign is better. (c–f) The changes in activity levels and signal flows after the inhibition of (c) GAB1, (d) IRS, (e) GS, and (f) PDK1.
