Figure 1

Matrix metalloproteinases (MMP)-2 and MMP-9 plasma levels over time. Paired points graphs demonstrated concentration (pg/mL) of MMP-2 (A) and MMP-9 (B) in plasma from non-infected individuals (NI, white, n = 5), patients with indeterminate (IND, gray, n = 15) and cardiac (CARD, dark gray, n = 11) clinical forms of Chagas disease, and from patients that had evolution of clinical forms during the cohort (EV, blue, n = 2). Proportion graphs demonstrated median for time zero (T0, black) over median for time one (T1, checkered). Statistical differences (p ≤ 0.05) between times were obtained by Wilcoxon signed-rank test and Mann-Whitney test, showed by asterisk (*).