Figure 3
From: Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling
Orally delivered SSRI require an intact vagus in order to exert antidepressant effects. (A) Time immobile in the tail suspension test (TST) following oral SSRI treatment. (B) Time immobile in the TST following oral NDRI treatment. (C) Time immobile in the TST following parenteral sertraline treatment. (D) Relative mRNA gene expression of hippocampal DCX, NeuroD1, BDNF and TrkB following sertraline treatment in control and vagotomised mice. Bars are means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, (behaviour, n = 12/group; PCR n = 8/group).
