Figure 5 | Scientific Reports

Figure 5

From: Human Adipose-derived Pericytes Display Steroidogenic Lineage Potential in Vitro and Influence Leydig Cell Regeneration in Vivo in Rats

Figure 5

Leydig cell steroidogenic mRNA expression. No difference in mRNA expression levels of luteinising hormone/chorionic gonadotropin receptor (Lhcgr); steroidogenic acute regulatory protein (Star); P450 cholesterol side-chain cleavage enzyme (Cyp11a1); hydroxysteroid dehydrogenase 3-beta (Hsd3b); or hydroxysteroid dehydrogenase 17-beta type 3 (Hsd17b3) was noted between experimental groups and Vehicle + Sham controls (1-way ANOVA). However, expression of 17α-hydroxylase, 17,20-lyase (Cyp17a1) was significantly increased both in hAd-PSC (EM) and in hAd-PSC (DIM) groups (1-way ANOVA; p = 0.0025). Tukey’s post-hoc analysis was used to compare means between groups. Groups that share a letter superscript are not significantly different. Data presented are mean ± SEM from n = 5–6 separate animals per group.

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