Figure 4 | Scientific Reports

Figure 4

From: Analysis of CT morphologic features and attenuation for differentiating among transient lesions, atypical adenomatous hyperplasia, adenocarcinoma in situ, minimally invasive and invasive adenocarcinoma presenting as pure ground-glass nodules

Figure 4

IAC in a 63-year-old man. (a) Reconstructive CT image showing typical creep growth (white arrow) and clear edge of the pGGN. The maximum diameter is 17 mm, and the maximum CT attenuation is relatively high (−552 HU). (b) Maximum intensity projection image showing a clear nodule-vessel interface. (c) Low-magnification image of a histologic specimen (haematoxylin-eosin, 40×) showing a clear boundary between the nodule edge and normal parenchymal structures (dotted black line). (d) High-magnification image (haematoxylin-eosin, 100×) showing a clear boundary between the nodule edge and the vessel adventitia (dotted black line). (e) High-magnification image (haematoxylin-eosin, 200×) showing crowded and overlapping tumour cells growing in clusters into the lumen (black line) with interstitial fibroblast involvement (▲).

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