Figure 6 | Scientific Reports

Figure 6

From: Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells

Figure 6

Presence of Multinucleated Giant Cells in human atherosclerotic plaques. (A) Representative pictures of cathepsin K stained human unstable plaques. Multinucleated Giant Cells are indicated by the arrow (B) MGCs are quantified as cells positive for cathepsin K and containing 2 or more round nuclei. (C) Pearson correlation analysis showing coefficient (p-values) between MGCs presence and MCL-1 gene expression levels in human unstable plaque segments (n = 18). (D) Heatmap showing Pearson’s correlation coefficient/p-values between the presence of MGCs and other clinical plaque traits. N = 22/23 (stable/unstable). *Indicates significant correlation.

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