Figure 8 | Scientific Reports

Figure 8

From: Interferon-Tau Exerts Direct Prosurvival and Antiapoptotic Actions in Luteinized Bovine Granulosa Cells

Figure 8

Illustrative summary depicting IFNT actions balancing life and death of bovine LGCs. IFNT elevates viable LGCs numbers, reduces apoptotic cells, and increases prosurvival proteins including XIAP, MCL1, and BCL-xL. Concurrently with its prosurvival effects, IFNT stimulates proangiogenic factors—FGF2, PDGFB. Conversely, antiapoptotic factors, active caspase-3, THBS2 and gH2AX are inhibited by IFNT. These findings portray IFNT as a prominent luteal survival factor.

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