Figure 6
From: A large intragenic deletion in the CLCN1 gene causes Hereditary Myotonia in pigs
Alignment of the CLC-1 protein reference sequences of 16 mammalian species between positions 60–90 (upper panel) and 930–960 (lower panel). Access numbers of each reference sequence are provided in the supplementary data (S Table 5). Gray-scale backgrounds indicate conservation level of acid residues among the sequences; white < 60% similarity, light gray ≥ 60 and < 80% similarity, dark gray ≥ 80% and < 100% similarity, and black 100% similarity. Highlighted in red are the two residue substitutions identified in myotonic animals (p.Met76Val and p.Ala920Val).
