Table 1 CRBN genotypes versus response and minimum residual disease status.

From: Cereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide

Response

MRD

Genotype

sCR

nCR/CR

VGPR

PR/SD

P (trend)a

OR (95% CI)

Pb

OR (95% CI)

Pb

MRD negative

MRD positive

P (trend)c

n (%)

n (%)

n (%)

n (%)

<sCR

<CR

n (%)

n (%)

CRBN rs1714327

CC

7 (41)

3 (18)

5 (29)

2(12)

0.55

Ref.

 

Ref.

 

12 (75)

4 (25)

0.80

CG

11 (65)

0 (0)

5 (29)

1 (6)

 

0.38 (0.08, 1.85)

0.30

0.78 (0.16, 3.84)

1.0

13 (76)

4 (24)

 

GG

4 (50)

1 (12)

2 (25)

1 (12)

 

0.70 (0.09, 5.27)

1.0

0.86 (0.10, 6.35)

1.0

6 (86)

1 (14)

 

CRBN rs1672753

CC

2 (67)

0 (0)

1 (33)

0 (0)

0.49

Ref.

 

Ref.

 

3 (100)

0 (0)

0.56

CT

6 (60)

1 (10)

3 (30)

0 (0)

 

1.33 (0.05, 98)

1.0

0.86 (0.03, 67.2)

1.0

7 (78)

2 (22)

 

TT

14 (52)

3 (11)

7 (26)

3 (11)

 

1.86 (0.09, 118)

1.0

1.18 (0.05, 76.3)

1.0

20 (77)

6 (23)

 

CRBN rs1045433

CC

—

—

—

—

0.54

    

—

—

0.14

CT

3 (43)

0 (0)

3 (43)

1 (14)

 

Ref.

 

Ref.

 

3 (50)

3 (50)

 

TT

20 (56)

3 (8)

9 (25)

4 (11)

 

0.60 (0.08, 4.17)

0.69

0.42 (0.05, 3.00)

0.4

28 (80)

7 (20)

 

CRBN rs1705814

CC

5 (62)

1 (12)

2 (25)

0 (0)

0.33

Ref.

 

Ref.

 

7 (100)

0 (0)

0.3

CT

12 (57)

0 (0)

6 (29)

3 (14)

 

1.25 (0.18, 10.2)

1.0

2.25 (0.29, 27.2)

0.67

15 (71)

6 (29)

 

TT

6 (40)

3 (20)

4 (27)

2 (13)

 

2.50 (0.32, 21.8)

0.40

2.00 (0.23, 26.1)

0.66

10 (71)

4 (29)

 

CRBN rs711613

CC

8 (47)

3 (18)

4 (24)

2 (12)

0.55

Ref.

 

Ref.

 

12 (75)

4 (25)

0.46

CT

10 (56)

0 (0)

5 (28)

3 (17)

 

0.71 (0.15, 3.26)

0.74

1.47 (0.31, 7.13)

0.73

12 (67)

6 (33)

 

TT

5 (62)

1 (12)

2 (25)

0 (0)

 

0.53 (0.06, 3.93)

0.67

0.61 (0.05, 5.17)

1.0

7 (100)

0 (0)

 
  1. aJonckheer-Terpstra test; bFisher’s exact test; cCochran-Amitage test.
  2. Abbreviations: CRBN, cereblon; sCR, stringent complete response; nCR, near complete response; CR, complete response; VGPR, very good partial response; PR, partial response; SD, stable disease; OR, odds ratio; CI, confidence interval; MRD, minimal residual disease.
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