Table 1 Mitochondria resident proteins showing a significant difference in expression due to GSTP-silencing.
Gene names | Representative property or function | Log2-fold change |
|---|---|---|
Up-regulated proteins | ||
MRPS36 | 28S ribosomal protein S36. MRPS36 is upregulated by excessive ROS, and functions as a ROS-sensing marker. | 4.983 |
UQCR10 | Subunit of mitochondrial complex III. | 3.197 |
COA3 | Stabilizer of cytochrome c oxidase, and essential for ROS generation. | 3.108 |
TOMM40 | Channel-forming protein essential for import of protein precursors into mitochondria. | 2.478 |
Down-regulated proteins | ||
PYCR2 | Loss of function leads to decreased mitochondrial membrane potential and increased susceptibility to apoptosis under oxidative stress. | −3.661 |
FAM162A | Involved in regulation of apoptosis and in hypoxia-induced cell death of transformed cells. | −3.339 |
REXO2 | Loss of function affects cellular morphology and leads cell cycle to G0/G1 arrest. | −3.272 |
SLC25A4 | Involved in mitochondrial ADP/ATP transport. Its silencing induces oxidative stress and apoptosis. | −3.205 |
SOD2 | Neutralize superoxide anion radicals. | −2.986 |
MRPL13 | Mitochondrial ribosomal protein L13. Its silencing lead to decrease production of mitochondrial proteins. | −2.954 |
CLIC4 | Inhibition of CLIC4 enhances autophagy and triggers mitochondrial and ER stress-induced apoptosis. | −2.918 |
NDUFB9 | Mitochondrial membrane respiratory chain NADH dehydrogenase. | −2.818 |
