Table 3 Association estimates between DNA methylation-based risk factors and conventional risk factors from the MCCS and meta-analysis.
Associations | MCCS women | MCCS men | AMDTSS + MCCS women | AMDTSS + MCCS women + MCCS men | ||||
|---|---|---|---|---|---|---|---|---|
β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI)a | P | |
Hannum clock | ||||||||
Age at first live birth | −0.01 (−0.08, 0.06) | 0.79 | −0.04 (−0.10, 0.01) | 0.14 | ||||
Ever smoking | 0.41 (−0.20, 1.02) | 0.19 | 0.16 (−0.34, 0.65) | 0.53 | 0.11 (−0.37, 0.60) | 0.65 | 0.08 (−0.28, 0.45) | 0.66 |
Horvath clock | ||||||||
Body mass index | 1.51 (−0.41, 3.43) | 0.12 | 1.37 (−0.68, 3.41) | 0.19 | 1.86 (0.38, 3.33) | 0.01 | 1.69 (0.49, 2.89) | 5.6E-03 |
Age at menarche | 0.13 (−0.08, 0.33) | 0.23 | 0.18 (0.02, 0.35) | 0.03 | ||||
Ever smoking | 1.03 (0.36, 1.71) | 2.8E-03 | 0.20 (−0.35, 0.74) | 0.48 | 0.77 (0.22, 1.31) | 5.8E-03 | 0.48 (0.10, 0.86) | 0.01 |
Levine clock | ||||||||
Body mass index | 3.03 (0.57, 5.48) | 0.02 | 4.80 (2.27, 7.34) | 2.1E-04 | 3.07 (1.24, 4.90) | 1.0E-03 | 3.66 (2.18, 5.15) | 1.3E-06 |
Pack-years of smoking | 0.28 (−0.26, 0.81) | 0.31 | 0.69 (0.33, 1.04) | 1.4E-04 | 0.54 (0.20, 0.88) | 2.1E-03 | 0.61 (0.36, 0.86) | 1.2E-06 |
Alcohol drinking | 0.09 (−0.75, 0.93) | 0.84 | 0.75 (−0.17, 1.66) | 0.11 | 0.54 (−0.12, 1.19) | 0.11 | 0.61 (0.08, 1.14) | 0.02 |
Ever smoking | 1.22 (0.34, 2.11) | 6.9E-03 | 1.21 (0.54, 1.88) | 4.2E-04 | 0.90 (0.25, 1.58) | 0.01 | 1.06 (0.58, 1.54) | 1.4E-05 |
Genome-wide average DNA methylationa | ||||||||
Number of live births | 0.03 (−0.07, 0.12) | 0.56 | −0.05 (−0.10, 0.004) | 0.07 | ||||
Age at first live birth | 0.001 (−0.01, 0.01) | 0.85 | 0.01 (0.00, 0.01) | 0.04 | ||||
Ever smoking | −0.06 (−0.14, 0.03) | 0.19 | −0.04 (−0.09, 0.004) | 0.08 | −0.04 (−0.09, 0.02) | 0.20 | −0.04 (−0.07, −0.01) | 0.03 |
