Figure 6
Example of lipid-dissolved 129Xe spectra acquired in WT and KO mice following adrenergic stimulation of iBAT. (a) Change in the lipid-dissolved xenon signal intensity before and after NE injection. Signal intensity is normalized by using the gas-phase peak, to correct for differences in 129Xe polarization between the two acquisitions. (b) Time series of spectra acquired from a WT mouse right after NE injection showing the temperature-induced frequency drift of the lipid-dissolved xenon peak for the same mouse shown in (a). (c) Time series of spectra acquired from a UCP1 KO mouse right after NE injection showing the temperature-induced frequency drift of the lipid-dissolved xenon peak. Please note that in (b,c) spectra amplitudes are scaled for clarity. All spectra were acquired using the non-localized sequence and corrected to remove fast-relaxing spin components originating from spins outside of the shimmed voxel.
