Figure 7
Box plots of maximum iBAT temperature increases above 34.5 °C for all animals as measured by XeMRT following norepinephrine injection. The mean ± standard deviation for each group of mice is as follows: (3.0 ± 0.5) °C for all n = 8 KO mice, (5.1 ± 1.2) °C for n = 8 WT mice, (3.1 ± 0.7) °C for n = 4 male KO mice, (4.9 ± 1.6) °C for n = 4 male WT mice, (2.9 ± 0.4) °C for n = 4 female KO mice, and (5.3 ± 0.8) °C for n = 4 female WT mice. The mean BAT temperature increase above 34.5 °C was significant in both WT (one-tailed t test, p < 3 × 10−6) and KO (one-tailed t test, p < 0.0001) groups. The difference in the mean BAT temperature increase between the WT and KO groups was also significant (two-sample t test, p < 0.0004, power = 0.995). No difference was observed between either male and female KO mice (two-sample t test, p = 0.55) or between male and female WT mice (two-sample t test, p = 0.70).
