Figure 1

Three-dimensional structure of the homology model of Ca2+-bound human CIB2. Protein secondary structure is shown as cartoons, EF1 is colored in yellow, EF2 is colored in green, EF3 is colored in orange, EF4 is colored in blue, the C-terminal helix is colored in cyan and Ca2+ ions are shown as red spheres. Residue E64 is shown as sticks. The structural model is from ref.8 (see Methods).