Table 3 Summary of IPA analysis based on rs3219175 associated plasma analytes.

From: Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation

Top Canonical pathways

p value

Overlapping genes

Genes

HMGB1 pathway

9.26E-10

4.2% 5/118

AGER, TGFB1, TGFB2, TNFRSF1A, TNFRSF1B

Hepatic Fibrosis/Stellate Cell Activation

3.68E-09

3.2% 5/155

VEGFR2, TGFB1, TGFB2, TNFRSF1A, TNFRSF1B

p38 MAPK Signaling

9.78E-08

4.0% 4/101

TGFB1, TGFB2, TNFRSF1A, TNFRSF1B

Hepatic Cholestasis

3.06E-07

3.0% 4/134

TGFB1, TGFB2, TNFRSF1A, TNFRSF1B

Tight Junction Signaling

3.25E-07

2.9% 4/136

TGFB1, TGFB2, TNFRSF1A, TNFRSF1B

Top Diseases and Bio Functions

p-value

Molecules

 

Inflammatory Response

3.84E-02–6.78E-07

4

 

Endocrine System Disorders

2.05E-03–8.13E-06

2

 

Gastrointestinal Disease

2.05E-03–8.13E-06

2

 

Metabolic Disease

2.05E-03–8.13E-06

2

 
  1. Ingenuity Pathway Analysis (IPA analysis): rs3219175 associated Chemokine and Cytokines.
  2. Plasma Chemokines and Cytokines associated with rs3219175 (see Table 2) were analyzed using IPA analysis (www.qiagenbioinformatics.com) for the enrichments of associated genes in the plasma with known biological pathways, diseases and bio-functions.
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