Table 4 Gene ontology by a component of the differently expressed proteins in the liver and the kidney extracted with electroporation mapped with GOrilla42.

From: Molecular harvesting with electroporation for tissue profiling

GO term

Description

P-value*

FDR q-value**

Enrichment (N, B, n,b)***

GO:0005739

mitochondrion

4.63E-37

5.23E-34

2.00 (1731, 429, 432, 214

GO:0044429

mitochondrial part

9.3E-20

5.26E-17

1.90 (1731, 235, 542, 140)

GO:0044444

cytoplasmic part

4.7E-16

1.77E-13

1.24 (1731, 1195, 428, 366)

GO:0005743

mitochondrial inner membrane

4.81E-16

1.36E-13

1.96 (1731, 144, 612, 100)

GO:0031966

mitochondrial membrane

9.05E-16

2.05E-13

2.22 (1731, 175, 401, 90)

GO:0043209

myelin sheath

7.47E-15

1.41E-12

2.30 (1731, 78, 597, 62)

GO:0019866

organelle inner membrane

2.18E-14

3.52E-12

1.97 (1731, 149, 559, 95)

GO:0043233

organelle lumen

1.2E-9

1.69E-7

2.30 (1731, 94, 408, 51)

GO:0070013

intracellular organelle lumen

1.2E-9

1.5E-7

2.30 (1731, 94, 408, 51)

GO:0031974

membrane-enclosed lumen

1.2E-9

1.35E-7

2.30 (1731, 94, 408, 51)

GO:0022627

cytosolic small ribosomal subunit

1.84E-9

1.89E-7

4.06 (1731, 20, 384, 18)

GO:0042579

microbody

3.44E-9

3.24E-7

2.61 (1731, 47, 480, 34)

GO:0005777

peroxisome

9.61E-9

8.36E-7

2.59 (1731, 46, 480, 33)

GO:0005759

mitochondrial matrix

1.65E-8

1.33E-6

2.20 (1731, 48, 623, 38)

GO:0031090

organelle membrane

3.01E-7

2.27E-5

1.56 (1731, 296, 401, 107)

  1. *‘P-value’ is the enrichment p-value computed according to the mHG or HG model. This p-value is not corrected for multiple testing of 731 GO terms. **‘FDR q-value’ is the correction of the above p-value for multiple testing using the Benjamini and Hochberg (1995) method. Namely, for the ith term (ranked according to p-value) the FDR q-value is (p-value * a number of GO terms)/i. ***Enrichment (N, B, n, b) is defined as follows: N - is the total number of genes. B - is the total number of genes associated with a specific GO term. n - is the number of genes in the top of the user’s input list or in the target set when appropriate. b - is the number of genes in the intersection. Enrichment = (b/n)/(B/N).
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