Table 5 Associations between myopia at age 7 and DNA methylation levels at CpG sites.

From: Grandmothers’ smoking in pregnancy is associated with a reduced prevalence of early-onset myopia

CpG site

Chr

Position

Gene

Age sample taken

Sex

Estimate

SE

P-value

n

Adjusted p-value

Potential genetic artefact*

cg26547698

16

89489058

ANKRD11

birth

 

−0.043

0.007

5.43E-09

862

0.003

yes

cg03905867

11

31821064

PAX6

birth

males

0.028

0.005

4.05E-08

421

0.019

no

cg06242000

3

183966155

ALG3

7

females

0.025

0.004

5.44E-08

465

0.026

yes

cg23680026

4

119200183

SNHG8

7

females

0.019

0.003

5.50E-09

465

0.003

no

cg12227341

2

99797610

MRPL30

15–17

 

0.007

0.001

5.47E-08

921

0.026

no

cg08656333

3

194218174

AX746839

15–17

 

−0.020

0.004

9.38E-08

921

0.044

no

cg12492276

12

109204605

SSH1

15–17

 

−0.056

0.010

3.14E-08

921

0.015

yes

cg02291011

1

111510137

LR1F1

15–17

males

−0.077

0.014

8.43E-08

445

0.040

yes

cg17241657

4

113152573

AP1AR

15–17

males

0.009

0.002

5.86E-08

445

0.028

no

cg23840823

4

1950185

WHSC1

15–17

males

0.099

0.018

1.04E-07

445

0.049

no

cg23249667

6

31515309

NFKBIL1

15–17

males

−0.003

0.000

1.90E-08

445

0.009

yes

cg05115182

10

99496889

ZFYVE27

15–17

males

0.020

0.004

6.95E-08

445

0.033

yes

cg19903001

10

70939225

SUPV3L1

15–17

males

0.059

0.011

1.05E-07

445

0.050

yes

cg06635871

12

7863853

DPPA3

15–17

males

0.080

0.014

3.79E-08

445

0.018

yes

cg00928894

16

188269

NPRL3

15–17

males

0.029

0.005

1.63E-08

445

0.008

no

cg24350392

17

37026147

LASP1

15–17

males

0.005

0.001

1.88E-08

445

0.009

no

cg16887862

1

1243669

ACAP3

15–17

females

0.014

0.003

9.19E-08

476

0.043

no

cg14673932

3

183872926

DVL3

15–17

females

0.009

0.002

2.14E-08

476

0.010

no

cg14119616

11

17099403

RPS13

15–17

females

0.008

0.001

9.57E-09

476

0.005

no

cg11451801

16

67970768

PSMB10

15–17

females

0.011

0.002

7.46E-09

476

0.004

no