Table 5 Associations between myopia at age 7 and DNA methylation levels at CpG sites.
From: Grandmothers’ smoking in pregnancy is associated with a reduced prevalence of early-onset myopia
CpG site | Chr | Position | Gene | Age sample taken | Sex | Estimate | SE | P-value | n | Adjusted p-value | Potential genetic artefact* |
|---|---|---|---|---|---|---|---|---|---|---|---|
cg26547698 | 16 | 89489058 | ANKRD11 | birth | −0.043 | 0.007 | 5.43E-09 | 862 | 0.003 | yes | |
cg03905867 | 11 | 31821064 | PAX6 | birth | males | 0.028 | 0.005 | 4.05E-08 | 421 | 0.019 | no |
cg06242000 | 3 | 183966155 | ALG3 | 7 | females | 0.025 | 0.004 | 5.44E-08 | 465 | 0.026 | yes |
cg23680026 | 4 | 119200183 | SNHG8 | 7 | females | 0.019 | 0.003 | 5.50E-09 | 465 | 0.003 | no |
cg12227341 | 2 | 99797610 | MRPL30 | 15–17 | 0.007 | 0.001 | 5.47E-08 | 921 | 0.026 | no | |
cg08656333 | 3 | 194218174 | AX746839 | 15–17 | −0.020 | 0.004 | 9.38E-08 | 921 | 0.044 | no | |
cg12492276 | 12 | 109204605 | SSH1 | 15–17 | −0.056 | 0.010 | 3.14E-08 | 921 | 0.015 | yes | |
cg02291011 | 1 | 111510137 | LR1F1 | 15–17 | males | −0.077 | 0.014 | 8.43E-08 | 445 | 0.040 | yes |
cg17241657 | 4 | 113152573 | AP1AR | 15–17 | males | 0.009 | 0.002 | 5.86E-08 | 445 | 0.028 | no |
cg23840823 | 4 | 1950185 | WHSC1 | 15–17 | males | 0.099 | 0.018 | 1.04E-07 | 445 | 0.049 | no |
cg23249667 | 6 | 31515309 | NFKBIL1 | 15–17 | males | −0.003 | 0.000 | 1.90E-08 | 445 | 0.009 | yes |
cg05115182 | 10 | 99496889 | ZFYVE27 | 15–17 | males | 0.020 | 0.004 | 6.95E-08 | 445 | 0.033 | yes |
cg19903001 | 10 | 70939225 | SUPV3L1 | 15–17 | males | 0.059 | 0.011 | 1.05E-07 | 445 | 0.050 | yes |
cg06635871 | 12 | 7863853 | DPPA3 | 15–17 | males | 0.080 | 0.014 | 3.79E-08 | 445 | 0.018 | yes |
cg00928894 | 16 | 188269 | NPRL3 | 15–17 | males | 0.029 | 0.005 | 1.63E-08 | 445 | 0.008 | no |
cg24350392 | 17 | 37026147 | LASP1 | 15–17 | males | 0.005 | 0.001 | 1.88E-08 | 445 | 0.009 | no |
cg16887862 | 1 | 1243669 | ACAP3 | 15–17 | females | 0.014 | 0.003 | 9.19E-08 | 476 | 0.043 | no |
cg14673932 | 3 | 183872926 | DVL3 | 15–17 | females | 0.009 | 0.002 | 2.14E-08 | 476 | 0.010 | no |
cg14119616 | 11 | 17099403 | RPS13 | 15–17 | females | 0.008 | 0.001 | 9.57E-09 | 476 | 0.005 | no |
cg11451801 | 16 | 67970768 | PSMB10 | 15–17 | females | 0.011 | 0.002 | 7.46E-09 | 476 | 0.004 | no |