Table 7 Capacity of DNA methylation to predict myopia assessed under 10-fold cross validation and measured as mean and standard deviation of area under the receiver operating characteristic curve (AUC) across the 10 folds.

From: Grandmothers’ smoking in pregnancy is associated with a reduced prevalence of early-onset myopia

Age samples taken

Sex

Myopia at 7

Myopia at 15

Difference between 7 and 15

Mean AUC

SD AUC

Mean AUC

SD AUC

p-value

Birth

 

0.64

0.11

0.57

0.04

0.17

males

0.75

0.14z

0.60

0.06

0.019

females

0.71

0.14

0.66

0.09

0.55

7y

 

0.62

0.11

0.57

0.09

0.20

males

0.72

0.12

0.58

0.09

0.019

females

0.85

0.14

0.56

0.05

0.0011

15–17y

 

0.60

0.12

0.58

0.06

0.71

males

0.80

0.11

0.62

0.09

0.0041

females

0.80

0.17

0.51

0.06

0.00088

  1. P-values are calculated using the Wilcoxon rank-sum sum test comparing the AUC values across the 10 folds.
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