Figure 2 | Scientific Reports

Figure 2

From: Radiation-induced malignancies after intensity-modulated versus conventional mediastinal radiotherapy in a small animal model

Figure 2

Tumor development in unirradiated and irradiated volumes: (a) control animals (AN/CBCT) developed spontaneous tumors only in the body parts equivalent to the NIRV of irradiated animals whereas only irradiated animals developed tumors in the LDV, BHDV and HDV, and the distribution of tumors in irradiated and unirradiated volumes was similar for the two prescribed doses, 3 × 5 Gy and 3 × 8 Gy; (b) no significant difference in the proportion of radiation-associated tumors (in the combined LDV/BHDV/HDV) was observed between the two RT techniques, VMAT and AP/PA (p = 0.29; Fisher’s exact test; α < 0.05). Abbreviations: NIRV, non-irradiated volume; LDV/BHDV/HDV, combined low-dose volume/bordering high-dose volume, and high-dose volume; AN/CBCT, anesthesia only and cone-beam computed tomography only control groups combined; Gy, Gray; RT, radiotherapy; VMAT, volumetric-modulated arc therapy; AP/PA, anterior-posterior/posterior-anterior irradiation.

Back to article page