Table 2 Number and entity of index tumors per volume. Bone sarcoma and carcinoma were frequent in unirradiated controls and non-irradiated volumes (NIRVs) of irradiated rats while lymphoma and soft tissue sarcoma were frequent in combined irradiated low-dose volume, bordering high-dose volume and high-dose volume (LDV/BHDV/HDV).

From: Radiation-induced malignancies after intensity-modulated versus conventional mediastinal radiotherapy in a small animal model

Volume

BSA

CA

SSA

BT

BC

LY

MM

ND

Total

♀

♂

AN/CBCT

13

4

1

2

2

—

—

5

14

13

NIRV 3 × 5 Gy/3 × 8 Gy combined

9

4

1

1

1

—

—

8

11

13

VMAT 3 × 5 Gy LDV/BHDV/HDV

3

1

2

—

—

3

1

—

5

5

AP/PA 3 × 5 Gy LDV/BHDV/HDV

—

1

2

—

—

4

—

—

4

3

VMAT 3 × 8 Gy LDV/BHDV/HDV

—

—

1

—

—

2

1

—

2

2

AP/PA 3 × 8 Gy LDV/BHDV/HDV

2

1

6

—

—

3

—

—

7

5

Total

27

11

13

3

3

12

2

13

43

41

  1. Abbreviations: BSA, bone sarcoma; CA, carcinoma, SSA, soft sarcoma; BT, brain tumor; BC, breast cancer; LY, lymphoma; MM, malignant mesothelioma; ND, not determined; NIRV, non-irradiated volume; Gy, Gray; AN, anesthesia only controls; CBCT, cone-beam computed tomography controls; VMAT, volumetric-modulated arc therapy; AP/PA, anterior-posterior/posterior-anterior irradiation; LDV/BHDV/HDV, low-dose volume, bordering high-dose volume, and high-dose volume combined (planned volume).
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