Figure 10
From: In vitro potentiation of doxorubicin by unseeded controlled non-inertial ultrasound cavitation
Cavitation setup. (A) The tank is filled with Ablasonic (a). The hydrophone (c) is placed in the solution between the two confocal transducers (b) and is directed towards the exposed sample contained in a 2 mL Eppendorf tube (d). (B) Schematic of the non-inertial cavitation control strategy. The control system is based on the alternation of high power pulses (Pmax) and low power pulses (Pmin). The level and type of cavitation are characterized by several indicators on the spectrum of the signal recorded by the hydrophone: occurrence of sub-harmonics (half the emission frequency) indicates non-inertial cavitation and high level of broadband noise indicates inertial cavitation. If the niCI (index of non-inertial cavitation) falls below a user-defined threshold (empirically defined at 3 in our case), a high power pulse is triggered to revive the cavitation cloud. The number of boosting pulses is recorded.
