Figure 5 | Scientific Reports

Figure 5

From: Binding partner- and force-promoted changes in αE-catenin conformation probed by native cysteine labeling

Figure 5

Coupling of the M domain with N and ABD indicated by cysteine labeling of R551A. (A). Labeling of αE-catenin R551A in the cadherin•β-catenin•R551A αE-catenin•vinculin D1 complex (8 technical replicates and three independent protein preparations), compared to that of R551A alone (see B). (B) Labeling of WT αE-catenin•cadherin•β-catenin (4 technical replicates and two independent protein preparations) and αE-catenin R551A•cadherin•β-catenin•D1complexes (same data as panel (A)). In each panel, p-values ≤ 0.05 are flagged with one star (*), ≤0.01 with two stars (**), and ≤0.001 with three stars (***).

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