Table 2 Phase-amplitude coupling (PAC) during the visual discrimination (VD) task.

From: Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology

Genotype

Brain Area

Freq

Condition

Mean

SD

Median

Range

N

Z

Prob > [Z]

p value rank

FDR threshold

WT

Cg

LG

Task_Start

0.000136

0.000054

0.000133

0.000150

8

−17

0.0156

7

0.0145833

Task_End

0.000060

0.000020

0.000066

0.000048

HG

Task_Start

0.000167

0.000056

0.000164

0.000201

−17

0.0156

6

0.0125

Task_End

0.000072

0.000034

0.000065

0.000094

HFO

Task_Start

0.000271

0.000060

0.000283

0.000193

−18

0.0078

1

0.0020833

Task_End

0.000138

0.000051

0.000143

0.000172

App NL-G-F

 

LG

Task_Start

0.000119

0.000074

0.000124

0.000214

7

−8

0.2188

20

0.0416667

Task_End

0.000073

0.000035

0.000085

0.000084

HG

Task_Start

0.000219

0.000173

0.000181

0.000506

−11

0.0781

15

0.03125

Task_End

0.000099

0.000040

0.000098

0.000120

HFO

Task_Start

0.000247

0.000090

0.000229

0.000249

−14

0.0156

8

0.0166667

Task_End

0.000135

0.000065

0.000099

0.000174

WT

dCA1

LG

Task_Start

0.000852

0.000477

0.000713

0.001435

10

−13.5

0.1934

19

0.0395833

Task_End

0.000719

0.000499

0.000732

0.001614

HG

Task_Start

0.003142

0.003040

0.001842

0.002389

−14.5

0.1602

18

0.0375

Task_End

0.002817

0.003087

0.001674

0.008305

HFO

Task_Start

0.001266

0.001129

0.000807

0.003486

−24.5

0.0098

4

0.0083333

Task_End

0.001019

0.001000

0.000786

0.003212

App NL-G-F

LG

Task_Start

0.000332

0.000204

0.000310

0.000581

6

1.5

0.8438

24

0.05

Task_End

0.000371

0.000320

0.000257

0.000816

HG

Task_Start

0.001877

0.001494

0.001523

0.004300

−3.5

0.5625

23

0.0479167

Task_End

0.001438

0.008713

0.001322

0.002162

HFO

Task_Start

0.000597

0.000397

0.000438

0.001036

−4.5

0.4375

22

0.0458333

Task_End

0.000398

0.000182

0.000377

0.000465

WT

DMS

LG

Task_Start

0.000176

0.000071

0.000156

0.000201

8

−15

0.0391

12

0.025

Task_End

0.000115

0.000036

0.000119

0.000092

HG

Task_Start

0.000434

0.000149

0.000443

0.000412

−16

0.0234

10

0.0208333

Task_End

0.000322

0.000130

0.000318

0.000340

HFO

Task_Start

0.000434

0.000112

0.000433

0.000326

−17

0.0156

5

0.0104167

Task_End

0.000276

0.000121

0.000296

0.000390

App NL-G-F

LG

Task_Start

0.000190

0.000074

0.000205

0.000205

7

−9

0.1563

17

0.0354167

Task_End

0.000136

0.000047

0.000158

0.000120

HG

Task_Start

0.000703

0.000571

0.000494

0.001642

−11

0.0781

14

0.0291667

Task_End

0.000535

0.000505

0.000267

0.001350

HFO

Task_Start

0.000350

0.000098

0.000360

0.000246

−11

0.0781

13

0.0270833

Task_End

0.000230

0.000154

0.000188

0.000480

WT

RSC

LG

Task_Start

0.000147

0.000071

0.000119

0.000218

9

−19.5

0.0195

9

0.01875

Task_End

0.000075

0.000023

0.000075

0.000067

HG

Task_Start

0.000177

0.000053

0.000181

0.000189

−21.5

0.0078

3

0.00625

Task_End

0.000091

0.000034

0.000087

0.000095

HFO

Task_Start

0.000309

0.000097

0.000326

0.000332

−21.5

0.0078

2

0.0041667

Task_End

0.000196

0.000068

0.000182

0.000178

App NL-G-F

LG

Task_Start

0.000130

0.000091

0.000089

0.000268

7

−6

0.375

21

0.04375

 

Task_End

0.000084

0.000043

0.000084

0.000129

HG

Task_Start

0.000202

0.000118

0.000188

0.000336

−10

0.1094

16

0.0333333

 

Task_End

0.000098

0.000044

0.000089

0.000120

HFO

Task_Start

0.000272

0.000089

0.000302

0.000225

−13

0.0313

11

0.0229167

 

Task_End

0.000166

0.000096

0.000155

0.000289

  1. Brain areas: Cingulate Cortex (Cg), dorsal CA1 region of the hippocampus (dCA1), dorsal medial striatum (DMS), and retrosplenial cortex (RSC).
  2. Frequencies: theta, gamma and high frequency oscillations (HFO).
  3. Conditions: Task_Start = start of the VD task, Task_End = end of the VD task.
  4. Descriptive statistics for Modulation Index (MI), N: sample size, Z: Wilcoxon rank-sum test.
  5. Significance level at q = 0.05, false discovery rate (FSD) corrected for multiple comparisons.
  6. Bold cells indicate statistically significant values. P value ranks lower than 8 are statistically significant different between the two conditions.
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