Figure 2 | Scientific Reports

Figure 2

From: An algorithm-based meta-analysis of genome- and proteome-wide data identifies a combination of potential plasma biomarkers for colorectal cancer

Figure 2

Classification accuracy of 96-paired samples – colorectal cancer tumor samples (CRC) and adjacent tissue (AT). Boxplot presenting discriminatory function score for CRC and AT groups (sum of the two to the power of Unshared Log Ratio scores reported in the study for selected proteins: PLOD1, P4HA1, LCN2, GNS, C12orf10, P3H1, TRIM28, CEACAM5, MAD1L1). Significant p values were calculated using double-sided Wilcoxon Signed Rank test for paired samples and Wilcoxon Rank Sum test for unpaired samples. The bars in the boxes represent median, 25th and 75th percentiles, while whiskers extend to ±2.7 σ. Numbers below the boxplots denote number of observations per category. (A) Discrimination between samples derived from tumor (CRC) and AT. (B) Discrimination between CRC and AT samples in males and females separately. (C) Discrimination between CRC and AT samples depending on histological subtype. (D) Discrimination between CRC and AT samples depending on the tumor stage. (E) Discrimination between CRC and AT samples depending on race. (F) Discrimination between CRC and AT samples depending on prior colon polyp history.

Back to article page