Figure 4
From: Development and validation of a targeted gene sequencing panel for application to disparate cancers
Rare variants are detectable in FPTS, OSCC and cSCC samples, at a similar ratio to online databases. Our validated panel was applied to cohorts of patients with FPTS (n = 18) (A), OSCC (n = 39) (B), and cSCC (n = 27) (C), for the detection of rare (≤1% control population) variations of various categories. Data for OSCC and cSCC was compared to TCGA and Pickering/Inman databases51,53, with genes arranged in order of most commonly mutated within those databases. Variants were restricted to high and medium impact. No such database exists for pituitary tumours, and genes were restricted to the 8 described in FPTS. Variants of any impact were included in the data presented herein for FPTS.
