Table 1 Binding affinities for ligands at primate AVPR1a.

From: Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors

AVPR1a

K i

125I-OVTA

Rank Order Potency

AVP

Leu8-OXT

Pro8-OXT

Bmax (fmol/well)

Kd (pM)

Human

0.63 ± 0.24

15.78 ± 0.33

8.71 ± 0.37

6.21

1165

AVP > Leu8 = Pro8

Macaque

1.21 ± 0.10

30.02 ± 0.16

23.77 ± 0.17

8.50

331

AVP > Leu8 = Pro8

Marmoset

0.86 ± 0.02

247 ± 0.06

175.9 ± 0.05

12.71

944

AVP > Leu8 = Pro8

  1. IC50 presented as nM ± Std. Error. Efficacy is presented as % maximum AVP response ± Std. Error. Human (n = 3); Macaque (n = 3); Marmoset (n = 5). Leu8 = Leu8-OXT; Pro8 = Pro8-OXT.
Back to article page