Table 1 Study cohort (n = 416) characteristics of the according classification criteria.

From: IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status

 

CD4+ T-cells ≤200 cells/µL

CD4+ T-cells >200 cells/µL

P- value

INR (n = 95)

IR (n = 106)

Control (n = 215)

Pre-ART clinical characteristics

Age at cART initiation (years)

42 [37–51]

37 [33–42]

37 [31–45]

<0.001

Male

58 (79)

70 (82)

155 (83)

0.807

Risk factor

   

0.060

   Heterosexual

29 (40)

31 (36)

62 (33)

 

   Homo/Bisexual

26 (36)

47 (55)

101 (54)

 

   Intravenous drug abuse

15 (20)

6 (7)

19 (10)

 

   Other/Unknown

3 (4)

2 (2)

5 (3)

 

CD4+ T-cell count (cells/µL)

51 [17–111]

129 [51–181]

333 [272–441]

<0.001

Plasma HIV RNA load (log copies/mL)

5.30 [4.82–5.62]

5.06 [4.71–5.61]

4.87 [4.33–5.25]

<0.001

AIDS indicator condition

30 (41)

21 (24)

13 (7)

<0.001

HCV co-infection (Positive)

13 (20)

10 (12)

27 (15)

0.410

ART clinical characteristics

48 weeks CD4+ T-cell count (cells/µL)

167 [110–216]

350 [294–422]

532 [408–699]

<0.001

ΔCD4+ T-cell count

95 [47–142]

239 [187–316]

170 [64–289]

<0.001

Pre-ART plasma IL-7/IL-7R (n = 345)

(n = 73)

(n = 86)

(n = 187)

 

Log IL-7 (pg/mL)

2.65 [2.53–2.82]

2.67 [2.54–2.81]

2.72 [2.60–2.99]

0.037

Log IL-7R (ng/mL)

2.34 [2.02–2.49]

2.33 [2.08–2.54]

2.34 [2.16–2.63]

0.264

  1. Data are presented as n (%) or median (interquartile range). Categorical data were compared by means of a χ2 test, whereas continuous data were compared using non-parametric Kruskall-Wallis test. P value < 0.05 was considered significant and is highlighted in bold. All P values > 0.05 but <0.15 were considered relevant for results interpretation and are italicized. AIDS was diagnosed according the CDC1993 criteria. INR, incomplete immune recoverers; IR, immune recoverers.
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