Figure 2
From: Natural phenolic compounds potentiate hypoglycemia via inhibition of Dipeptidyl peptidase IV
Inhibition of DPP IV activity via natural compounds. The (A) enzymatic inhibition of DPP IV activity were determined after treating with P32/98 (Con), curcumin (Cur), resveratrol (Res), sitagliptin (DPP4i), curcumin mixed with berberine (Ber), antroquinonol (A), and 16-hydroxycleroda-3,13-dien-15,16-olide (HCD), respectively. (B) In Caco-2 cells, time-dependent with 10 μM of curcumin (Cur) and 10 nM of sitagliptin (DPP4i) for 12, 24, and 36 h, respectively. And dose-dependent with 10, 20, 30 μM of Cur and 10, 50, and 100 nM of DPP4i for (C) 12 h and (D) 24 h manner in Caco-2 cells, respectively. Data are expressed as means with standard deviations (mean ± SD). **P < 0.01; ***P < 0.001 vs. DPP IV (A) or control (B–D) with one-way ANOVA.
