Figure 2

16S rDNA sequencing. Principal Coordinate Analysis (PCoA) based on Bray-Curtis dissimilarity between all samples (panels A,B). PCoA plots show pre- and post-treatment gut microbiome signatures in all individual mice, group means are indicated by a large point. Microbial diversity analysis at genus level, including sample (OTU) richness (C) and Shannon alpha diversity (D). *p < 0.05, **p < 0.01, ***p < 0.001 vs. corresponding sampling time in DIO vehicle mice; #p < 0.05, ##p < 0.01 vs. corresponding baseline.