Figure 4

Shotgun metagenomics. Principal Coordinate Analysis (PCoA) based on Bray-Curtis dissimilarity between all samples calculated using species relative abundances (panels A,B). PCoA plots demonstrate pre- and post-treatment gut microbiome signatures in all individual mice, group means are indicated by a large point. Microbial diversity analysis at species level, including gene richness (C) and Shannon alpha diversity (D). ***p < 0.001 vs. corresponding sampling time in DIO vehicle mice.