Table 3 Mummichog v2.0 based pathway correction of radiation injury in bone marrow by treatment of amifostine 50 mg/kg.
From: Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation
Pathway | Day 4 | Day 9 | ||
|---|---|---|---|---|
overlap size | p-value | overlap size | p-value | |
Prostaglandin formation from arachidonate | 3(7)a | 8.40E-05 | 0(7) | 1.68E-02 |
Linoleate metabolism | 3(7) | 3.36E-04 | 0(3) | 1.68E-02 |
Di-unsaturated fatty acid beta-oxidation | 2(3) | 9.24E-04 | 0(1) | 1.68E-02 |
D4&E4-neuroprostanes formation | 0(2) | 3.70E-02 | 1(2) | 3.02E-03 |
Carnitine shuttle | 4(22) | 5.29E-03 | 0(2) | 1.68E-02 |
Fatty acid metabolism | 2(5) | 5.29E-03 | 0(1) | 1.68E-02 |
Xenobiotics metabolism | 1(1) | 8.57E-03 | 0(1) | 1.68E-02 |
Arachidonic acid metabolism | 2(8) | 8.57E-03 | 0(8) | 1.68E-02 |
Ascorbate (vitamin C) and aldarate metabolism | 1(1) | 8.57E-03 | 0(1) | 1.68E-02 |
Glutamate metabolism | 1(1) | 8.57E-03 | 0(1) | 1.68E-02 |
Leukotriene metabolism | 2(8) | 8.57E-03 | 0(8) | 1.68E-02 |
Pyruvate metabolism | 1(1) | 8.57E-03 | 0(1) | 1.68E-02 |
Glycerophospholipid metabolism | 3(16) | 1.44E-02 | 0(10) | 1.68E-02 |
Tryptophan metabolism | 1(2) | 1.60E-02 | 0(2) | 1.68E-02 |
Glutathione metabolism | 1(2) | 1.60E-02 | 0(2) | 1.68E-02 |
Aspartate and asparagine metabolism | 1(2) | 1.60E-02 | 0(2) | 1.68E-02 |
Putative anti-Inflammatory metabolites formation from EPA | 1(2) | 1.60E-02 | 0(2) | 1.68E-02 |
Fatty acid activation | 2(8) | 1.61E-02 | 0(3) | 1.68E-02 |
Vitamin A (retinol) metabolism | 0(7) | 3.70E-02 | 0(7) | 1.68E-02 |
De novo fatty acid biosynthesis | 2(9) | 1.97E-02 | 0(4) | 1.68E-02 |
Glycine, serine, alanine and threonine metabolism | 1(3) | 2.48E-02 | 0(3) | 1.68E-02 |
Androgen and estrogen biosynthesis and metabolism | 1(3) | 2.48E-02 | 0(3) | 1.68E-02 |
Tyrosine metabolism | 1(6) | 3.28E-02 | 0(6) | 1.68E-02 |
Methionine and cysteine metabolism | 1(3) | 2.48E-02 | 0(3) | 1.68E-02 |
Histidine metabolism | 1(4) | 2.76E-02 | 0(4) | 1.68E-02 |
