Table 4 Mummichog v2.0 based pathway correction of radiation injury in bone marrow by treatment of amifostine 200 mg/kg.
From: Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation
Pathway | Day 4 | Day 9 | ||
|---|---|---|---|---|
overlap size | p-value | overlap size | p-value | |
Tyrosine metabolism | 10(10)a | 1.13E-02 | 9(10) | 1.09E-03 |
Androgen and estrogen biosynthesis and metabolism | — | — | 6(6) | 1.60E-03 |
Phosphatidylinositol phosphate metabolism | 5(5) | 5.55E-03 | 5(5) | 4.45E-03 |
Leukotriene metabolism | 4(4) | 4.36E-02 | 4(4) | 1.08E-02 |
Histidine metabolism | 4(4) | 1.11E-02 | — | — |
Carnitine shuttle | — | — | 15(22) | 1.35E-02 |
Bile acid biosynthesis | — | — | 4(4) | 1.63E-02 |
Glycerophospholipid metabolism | — | — | 8(10) | 2.16E-02 |
Purine metabolism | — | — | 5(6) | 2.26E-02 |
Glycosphingolipid biosynthesis - ganglioseries | 3(3) | 2.53E-02 | 3(3) | 2.37E-02 |
Glycine, serine, alanine and threonine metabolism | 5(5) | 2.51E-02 | 3(3) | 2.37E-02 |
Methionine and cysteine metabolism | 5(5) | 2.51E-02 | 3(3) | 2.37E-02 |
Linoleate metabolism | 3(3) | 2.53E-02 | 3(3) | 2.37E-02 |
Vitamin A (retinol) metabolism | — | — | 6(7) | 2.41E-02 |
Vitamin E metabolism | 3(3) | 2.53E-02 | — | — |
Arachidonic acid metabolism | — | — | 3(3) | 2.59E-02 |
Selenoamino acid metabolism | — | — | 3(3) | 2.59E-02 |
Pentose phosphate pathway | — | — | 3(3) | 2.59E-02 |
Prostaglandin formation from arachidonate | — | — | 6(8) | 3.45E-02 |
Sialic acid metabolism | 5(6) | 3.66E-02 | 5(6) | 3.48E-02 |
Xenobiotics metabolism | 7(7) | 3.50E-02 | — | — |
Aspartate and asparagine metabolism | 4(4) | 4.36E-02 | — | — |
