Figure 6 | Scientific Reports

Figure 6

From: Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels

Figure 6The alternative text for this image may have been generated using AI.

Sensitivity of SVD to TEA induced by KYN (a), TON (b), and DIO (d) and sensitivity of MSN-induced SVD to CFTR-inh or SQ22536 (c) in Caco-2 cells. Top panels: Time courses of changes in the mean cell volume. At time 0, each herbal component (400 μg/ml) was applied alone (open circles) or together with 5 mM TEA (filled circles), 10 μM CFTR-inh (filled triangles), or 100 μM SQ22536 (filled diamonds). Bottom panels: Percentage of the cell volume after 30 min of treatment relative to the initial cell volume. Each column represents the mean ± S.E.M. (n = 5). *P < 0.05 compared with the data of each herbal component alone.

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