Figure 1 | Scientific Reports

Figure 1

From: Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis

Figure 1

Genetic deletion of functional TLRs 2 and 4 significantly impairs survival of mice inoculated centrally with S. pneumoniae. WT = wild-type; GKO = gene knockout. The disease course of pneumococcal meningitis in WT (filled square) and GKO (unfilled square) mice was monitored up to day 9 post-inoculation (p.i., ∼5 × 105 cfu S. pneumoniae/mouse) when (A) antibiotic ceftriaxone treatment was not administered or when (B) treatment was initiated at 20 h p.i. A death event was recorded when mice developed severe disease signs requiring euthanasia. Data are presented as percentage of survival at each time point, with total n = 25 WT or 26 GKO mice in three independent experiments. **p < 0.01, Log-rank test.

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