Figure 2 | Scientific Reports

Figure 2

From: Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis

Figure 2

Genetic deletion of functional TLRs 2 and 4 modifies the inflammatory response in mice with pneumococcal meningitis. The CSF levels of IFN-γ, IL-6, IL-1β, TNF and CCL2 were measured at (A) 20 h p.i and (B) 24 h following the first dose of antibiotic treatment (=44 h p.i.). Antibiotic treatment commenced at 20 h p.i on all mice. WT = wild-type; GKO = gene knockout. Total n = 2–3 mice per WT or GKO sham group or n = 6–8 per WT or GKO meningitis group. *p < 0.05, **p < 0.01, ***p < 0.001, planned comparisons between sham-inoculated and meningitis groups of either genotype as well as between WT and GKO meningitis groups on log-transformed data.

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